While CRS without nasal polyps was traditionally more strongly associated with TAS2R38 expression [51], recent literature has demonstrated that TAS2R38 is expressed in nasal polyps and that patients with advanced CRS with nasal polyps (CRSwNP) show decreased TAS2R38 expression in their nasal mucosa compared to healthy controls [52]. The gene discussed is TAS2R38; the disease is congenital rubella syndrome.