TAS2R8 and central nervous system cancer: While little research on TAS2R expression in neurologic disease is published, murine neuroblastoma cells induced to express TAS2R8 and TAS2R10 saw decreased expression of tumorigenic markers including hypoxia-inducible factor-1 alpha, decreased proliferation, and decreased tumor cell migration [89] and a human genome-wide association study found the rs667128 SNP on TAS2R7 and the rs1033583 SNP on TAS2R8 to be associated with glioma risk [127].