Activation of the MET signaling pathway in the PMN not only enhances tumor cell migration and invasion, but also promotes neo-angiogenesis.476 MET shows aberrant activation in a variety of cancers, which is intimately associated with the growth, proliferation and invasive ability of tumor cells.477 Therefore, blocking the HGF/MET signaling pathway can effectively inhibit tumor development and metastasis. Here, HGF is linked to neoplasm.