NGFR and melanoma: This prepares them as hospitable and supportive ecological niches for disseminated tumor cells.235,236 The PMN within the lymph node is distinguished by lymphangiogenesis and the restructuring of high endothelial venules, with lymphatic vessels serving as the primary conduit for tumor dissemination through the lymphatic system.235,237,238 Melanoma-derived EVs can be absorbed by lymph node endothelial cells and enrich nerve growth factor receptor (NGFR).