Shen et al. developed pH-sensitive nanoparticles for the combined delivery of BLZ-945 and platinum to consume TAMs and kill tumor cells, achieving a combination of chemotherapy and immunotherapy.343,344 Studies have demonstrated the effectiveness of CSF-1R inhibitor-loaded nanoparticles in consuming TAMs and inhibiting tumor growth and metastasis.344 Surface markers on macrophages, like CD206, can likewise serve as therapeutic targets. This evidence concerns the gene MRC1 and neoplasm.