CECR1 promotes the release of PDGFB from macrophages, thereby activating the PDGF-B/PDGFR-β pathway in pericytes, leading to the production of the Periostin protein and ultimately promoting angiogenesis.225,226 Cancer-derived exosome-mediated miR-25-3p can downregulate KLF2, KLF4, ZO-1, occludin, and Claudin5 while upregulating VEGFR2 prior to metastasis. The gene discussed is PDGFB; the disease is cancer.