These factors collectively foster an environment conducive to the establishment of diverse cancer cell types in the liver and their subsequent dissemination.261 In the realm of colorectal cancer liver metastasis, increased YAP activity in fatty liver promotes cancer cell growth and creates an immunosuppressive microenvironment infiltrated by M2 macrophages that produce CYR61.262 High CD36 expression in tumor cells triggers metastasis through a distinct mechanism. The gene discussed is CCN1; the disease is cancer.