These discoveries indicate that tumor-derived exosomes, via glycolytic metabolism, can reprogram macrophages and play a role in establishing an immunosuppressive milieu within the PMN.27,209 Besides that, primary tumor-derived miR-122 can also inhibit glucose uptake and utilization in cells within the PMN by down-regulating glycolytic enzymes and pyruvate kinases, thereby achieving energy metabolism reprogramming to promote metastasis.210. The gene discussed is HK1; the disease is neoplasm.