INS and Insulin resistance: Interestingly, several studies reported that MU individuals, defined as having elevated levels of homoeostasis model assessment of insulin resistance (HOMA-IR) index, fasting insulin, C-peptide, or having more than one metabolic abnormality, were at greater risk of developing colorectal, breast, pancreatic, and bladder cancers, regardless of whether they were normal weight or overweight/obese when compared with individuals who are metabolically healthy and normal weight (MHNW) [15–20].