INS and obesity due to melanocortin 4 receptor deficiency: However, despite excess body weight and hyperinsulinemia having been reported to be associated with an increased risk of cancer, it is unclear whether the risk of obesity-related cancers differs between individuals who are metabolically healthy (i.e., normal insulin sensitivity) with overweight/obesity (MHOW/OB), those with metabolically unhealthy (i.e., insulin resistance) overweight/obesity phenotypes (MUOW/OB) and those with metabolically unhealthy normal weight (MUNW).