HCRT and mood disorder: Modulation of orexin neuron circuitries through novel pharmacological approaches could assist in modulating neuropsychiatric pathologies characterized by aberrant motivation, including substance use and mood disorders (James et al., 2020; James & Aston-Jones, 2020; James et al., 2021; Fragale, James, Avila, et al., 2021; Mehr, Bilotti et al., 2021; Zhang et al., 2024).