C9orf72 and neurodegenerative disease: Despite these limitations, the consistency of proteomics results obtained from the motor neurons sorted from our zebrafish model with iPSCs from patients carrying C9orf72 HRE, as well as the similar accumulation of poly(GP) assessed by immunoassay both in patient brain autopsy samples and zebrafish samples further support the proximity and translability of this zebrafish model, further our understanding of potential pathogenic mechanisms due to poly(GP) repeats and describes therapeutic strategies for ALS, FTD and related neurodegenerative diseases.