Previous studies in pediatric patients with COVID-19 reported a seropositivity rate ranging from 35% for S IgM, 25%-100% for S IgG, and 93% for N IgG during acute infection (<4 weeks) to 50% for S IgM, 63%-100% for S IgG, and 92%-100% N IgG during convalescent infection (4 weeks-6 months after disease onset) [5, 6, 35, 36]. This evidence concerns the gene CD40LG and infection.