While the liver is not the primary target organ of SARS-CoV-2 infection, human hepatocellular carcinoma Huh-7.5 cells naturally express SARS-CoV-2 dependency factors, including the receptor angiotensin converting enzyme 2 (ACE2), and proved unexpectedly useful in SARS-CoV-2 research [19,27–34]. Here, ACE2 is linked to hepatocellular carcinoma.