POLR2A and infection: We observed that degradation of RPB1 mediated by polyubiquitination of K1268 is not involved in the loss of pS2/7 but moderately stabilizes RPB1 24 h p.i. This suggests that there are multiple degradation pathways triggered by HSV at different stages of infection and reside in a balance with ongoing viral transcription or trafficking between VICE domains and replication compartments (RCs).