LZTR1 encodes an adaptor for a ubiquitin-ligase that degrades the RAS-GTP protein RIT1, and interestingly, mutations within the LZTR1 minor intron or activating mutations in RIT1 have been described in the Rasopathy Noonan syndrome as well as myeloid leukemias (Inoue et al., 2021). The gene discussed is LZTR1; the disease is myeloid leukemia.