The enrichment of SF3B1 mutations in MDS-RS has led to several groups finding that SF3B1 mutations lead to coordinated mis-splicing of the mitochondrial transporters TMEM14C and ABCB7, which results in iron sequestration within the mitochondria (Dolatshad et al., 2015, 2016; Clough et al., 2022; Alsafadi et al., 2016; Ochi et al., 2022). The gene discussed is SF3B1; the disease is myelodysplastic syndrome.