In a recent study, we further provided morphological and electrophysiological evidence showing that hyperactivated MD preferentially recruited postsynaptic PV+ neurons (not their glutamatergic and SST‐expressing counterparts) under the condition of post‐traumatic stress disorder (PTSD), which played a critical role in mediating abnormal fear extinction.[39] In this study, we observed that postsynaptic PV‐ and SST‐INS, instead of their glutamatergic counterparts, of this pathway promoted acute itch‐induced scratching. Here, INS is linked to post-traumatic stress disorder.