These encompass critical pathways such as cell cycle regulation, senescence, embryonic development, and stem cell differentiation.[9, 10, 11] Earlier investigation has unveiled that Sin3B expression is elevated in preneoplastic lesions which is required for oncogenic Kras‐induced senescence in vivo.[12] However, the role of Sin3B in tumor immune evasion remains unexplored. This evidence concerns the gene SIN3B and neoplasm.