To elucidate SIN3B's role in pancreatic ductal adenocarcinoma (PDAC), we employed CRISPR‐Cas9 to specifically knock out (KO) Sin3B in the murine PDAC cell line KPC1199, derived from KPC mouse model (Pdx‐cre, LSL‐KrasG12D, Trp53R172H). The gene discussed is SIN3B; the disease is pancreatic ductal adenocarcinoma.