EGFR and posterior cortical atrophy: Conversely, Zhang and colleagues have observed that miR-146a-5p is downregulated in sEVs obtained from CAFs after hormonal therapy, contributing to the acquisition of a metastatic phenotype by recipient PCa cells through the activation of the epidermal growth factor receptor (EGFR)/extracellular signal regulator kinase (ERK) signaling [27].