Similarly, Sequeiros and collaborators have identified a two-protein combination in urinary small vesicles that classifies benign and PCa patients (ADSV-TGM4) and a combination of five proteins able to significantly distinguish between high- and low-grade PCa individuals (CD63-GLPK5-SPHM-PSA-PAPP) [132]. Here, CD63 is linked to posterior cortical atrophy.