Finally, Wang and colleagues have shown that plasma levels of sEV SAP30L-AS1 are upregulated in BPH, whereas sEV SChLAP1 is significantly overexpressed in PCa individuals; in particular, SAP30L-AS1 expression correlates with PSA values and tumor invasion, while SChLAP1 levels are associated with Gleason score, also helping to differentiate between BPH and PCa when the concentration of PSA is in the gray zone [126]. This evidence concerns the gene KLK3 and benign prostatic hyperplasia.