IL6 and posterior cortical atrophy: Similar results have been obtained in two recent studies exploring the role of miR-let-7 family, especially miR-let-7b and miR-let-7b-5p, in PCa immune evasion [57, 58]; on the other hand, Zhang and colleagues have recently reported that sEV-shuttled miR203 not only suppresses hormone-responsive PCa invasion in vitro and in vivo but it also triggers macrophage switch toward the M1 state, stimulating the accumulation of IL-1β, IL-6, IL-12, CXCL9, and CXCL10 in the TME and facilitating cancer eradication [59].