HYAL1 and neoplasm: Similarly, high levels of hyaluronidase 1 (Hyal1), an enzyme involved in hyaluronic acid turnover and responsible for increased PCa cell motility, have been detected in tumor sEVs [18]; treatment of prostate fibroblasts with these particles does not affect their proliferation but significantly fosters their migratory behavior through the engagement of the focal adhesion kinase (FAK)-mediated integrin cascade [19].