Similar observations have been reported for circHIPK3 and circ-0081234, found to be overexpressed in small vesicles from both the serum of PCa patients and supernatant of PCa cells and to stimulate the growth and invasion of recipient tumor cells via miR-212/B-cell-specific MMLV insertion site-1 (BMI-1) and miR-1/MAP3K1 axis, respectively [101, 102]. Here, MAP3K1 is linked to posterior cortical atrophy.