Indeed, Jiang and coworkers have reported that the lncRNA HOXD-AS1 is highly present in hormone-insensitive cells as well as in their vesicles; when taken up by hormone-responsive cells, vesicular HOXD-AS1 significantly increases tumor migration, by inducing E-cadherin downregulation and vimentin upregulation [96]. The gene discussed is HAGLR; the disease is neoplasm.