Parallelly, Patel and colleagues have found that suppression of miR-200c-3p correlates with upregulation of TBX2, a NED-related T-box transcription factor regulating SOX2 and N-MYC expression; of note, low levels of miR-200c-3p have been observed in small vesicles from TBX2-overexpressing PCa cells, allowing the propagation of neuroendocrine-like features across the entire tumor bulk [86]. Here, TBX2 is linked to neoplasm.