In particular, it has been reported that vesicles from hypoxic tumor cells confer invasive and stem-like features to their normoxic counterpart; these effects are mediated by the activation of MMPs and enhanced synthesis of protumoral biofactors (TNFα, TGF-β, IL-6) as well as by a deep rearrangement in the epithelial adherens junctions [17]. Here, TGFB1 is linked to neoplasm.