TOMM40 is a translocase located in the outer membrane of the mitochondria that has been implicated in tissue protective effects against late-onset Alzheimer disease (Chiba-Falek et al., 2018) and COX6C is the terminal enzyme of the mitochondrial respiratory chain, catalyzing the electron transfer from reduced cytochrome c to oxygen. This evidence concerns the gene COX6C and early-onset autosomal dominant Alzheimer disease.