Meanwhile, TNF‐α−857 showed no association with the risk of cirrhosis in our study, aligning with a study by Panigrahi et al.30However, it has been shown that the TNF‐α−857 T allele was an independent risk factor for the development of HCC in patients with HBV‐associated LC (HR, 6.29; 95% CI, 1.62–24.43).31 This evidence concerns the gene TNF and laryngotracheoesophageal cleft.