One of these proteins, the RhoGAP ARHGAP29, has been shown to regulate mechanotransduction in a YAP-dependent manner and to control cancer cell migration and invasion by suppressing actin polymerisation through a Rho/LIMK/cofilin pathway (Meng et al., 2018; Qiao et al., 2017). The gene discussed is LIMK1; the disease is cancer.