TOP2A and tuberculosis: Absent in higher eukaryotes but essential in all bacteria,DNA gyrase is the only clinically validated target of the MTB DNAreplication machinery.40 As pillars ofMDR-TB regimens, FQ drive TB lesion sterilization via potent cidalactivity against NRP MTB subpopulations in hard-to-treat necroticlesion compartments.6 Importantly, MXFis featured in several new regimens that recently entered phase 2band phase 3 clinical trials for the treatment of drug-susceptibleand MDR pulmonary TB.