The first variant—R1267Q—is the only one localizing in Ig11 repeat of ROD1 domain of filamin C. Several other mutations localizing in the neighboring domains have been described associated with all types of cardiomyopathies—dilated, arrhythmogenic, hypertrophic, and restrictive (Eden & Frey, 2021), therefore the detailed molecular mechanisms of R1267Q pathological effect cannot be simply attributed to the variant location. This evidence concerns the gene FLNC and cardiomyopathy.