MFN2 and amyotrophic lateral sclerosis: TDP-43 bound mitochondrial mRNAs, especially with amyotrophic lateral sclerosis–causing mutations.42,43 Knocking down TARDBP reduced MFN2 and blocked its mitochondrial association, improving neuromuscular function in mutant mice.42,43 In Drosophila, overexpressing Marf was able to mitigate TDP-43-induced disease.45