SPG11 and amyotrophic lateral sclerosis: Lately, a growing number of genes have been linked to both Charcot–Marie–Tooth disease type 2 and amyotrophic lateral sclerosis (i.e. CHCHD10, GARS, FIG4, KIF5A, NEFH, VCP and SPG11),7 suggesting a genetic overlap between the two diseases, although further studies are needed to confirm this association.