Abdelkader et al. (2022) found that inosine alleviated pain through downregulation of PKC, TRPV1 expression, decreasing Substance P and Transforming growth factor beta in DPN rat model. α-lipoic acid (ALA) may alleviate NeuP in diabetes by regulating TRPV1 expression via affecting NF-κB (Wang Z. et al., 2020). SUMOylation is an important mechanism for protection against endogenous metabolic damage in DPN sensory neurons, and modulation of TRPV1 function through extra-sensory neuronal SUMOylation may yield novel strategies for treating and reversing DPN (Truini et al., 2015). Here, TRPV1 is linked to diabetes mellitus.