The gene expression analysis of the Th1 and Th2 cell differentiation pathways in the bone marrow samples of RA and OA patients in the GSE100786 dataset revealed that MAPK8IP3, a component of the MAPK8 pathway, had significant upregulation in the RA group (logFC =2.066, adjusted p=0.0019 (Fig. 3A). This evidence concerns the gene MAPK8 and rheumatoid arthritis.