While this interaction between neutrophil and B-cells is not observed in our data, likely due to cells being sourced from peripheral blood as opposed to the lesional skin, we do observe an interaction between BAFF-BAFFR and BAFF-TACI occurring between monocytes and plasmablasts, suggesting a similar mechanism of B-cell activation may be mediated by both neutrophils and monocytes in the pathogenesis of HS. The gene discussed is TNFRSF13B; the disease is histiocytic sarcoma.