CDKL5 and bipolar disorder: Given that extreme sleep dysregulation was an important component of this individual’s presentation leading to her diagnosis with bipolar disorder, and that no other individuals with a formally diagnosed mood disorder were identified from our CDD cohorts, we reviewed the cohort of patients enrolled under the CDKL5 Clinic Study observational protocol at Boston Children’s Hospital (IRB-P00016602) for individuals exhibiting similarly extreme sleep disturbances.