Inspecting the top 20 most informative CpGs of our stratification model revealed heavily weighted CpGs in genes implicated in asthma pathogenesis and regulation of airway inflammation and remodeling (STAT3, RASSF1, MEOX1)32–34, bronchodilator response (DDX54)35, and asthma severity and lung function (ALDH2)36,37 (Supplementary Tables S5 and S6). Here, ALDH2 is linked to asthma.