The results showed significant associations of HIF1A (OR [95 %] = 0.78 [0.65, 0.94], p = 0.008) and CCND1 (OR [95 %] = 1.22 [1.00, 1.49], p = 0.04) with tinnitus in MR analysis IVW results (Fig. 5, Fig. 6). This evidence concerns the gene CCND1 and Tinnitus.