The patients with COVID-19 in ICU were critically ill who typically were of older age, or had more severe inflammatory responses such as CRP; PCT, abnormal coagulation, or comorbidities with various organ dysfunctions such as cardiac, hepatic, renal, etc.Neutralizing monoclonal antibodies (mAbs) may be somewhat less effective in these patients.This study also shows that the mortality rate of severe patients is about 45.45 %, and the viral negative conversion rate is 57.85 %. Here, CRP is linked to COVID-19.