Sustaining proliferative signaling:  The homotrimeric form of Collagen Type 1 (Col1   α1/α1/α1) derived from pancreatic cancer cells has been   demonstrated to facilitate oncogenic signaling via   DDR1 and integrin α3β1. This process results in an   increased abundance of Bacteroidales within the   intratumoral microbiome. The gene discussed is DDR1; the disease is pancreatic neoplasm.