CD8A and metabolic dysfunction-associated steatotic liver disease: Inflamation:  The dysbiosis of the gut microbiota, along with gut   microbiota-mediated inflammation of the intestinal   mucosa, was evident in NAFLD patients. This   inflammatory response was characterized by decreased   numbers of CD4+ and CD8+ T lymphocytes and increased   levels of TNF-α, IL-6, and IFN-γ in the NAFLD group   compared to the healthy group. These factors, along with   the related impairment in mucosal immune function, play   a significant role in the pathogenesis of NAFLD.