- In experiments with mice and in laboratory studies,   lithocholic acid (LCA), a secondary bile acid, decreased   cancer cell proliferation and VEGF production, as well   as reduced the aggressiveness and metastatic potential   of primary tumors.- BC patients reduced abundance of baiH in Clostridium   sordelli, Pseudomonas putida, and Staphylococcus   aureus. In early-stage BC patients, a more significant   decline in the abundance of baiH in Bacteroides   thetaiotaomicron and Pseudomonas putida   was observed.. The gene discussed is VEGFA; the disease is cancer.