In CD14.Mn.S100A8.9hi cluster, cancer-specific genes of interest included SIGLEC1, MX1, FKBP5, AREG, HBEGF, LYZ, OAS1, CEBPD, FABP5, MARCO, CD163, DAPK1, and PECAM1 among others, related to interferon alpha/gamma pathway, glycolysis, MTORC1 signaling, hypoxia, endocytosis receptor activity, and serine/threonine kinase activity (Figures 1D, E). This evidence concerns the gene HBEGF and cancer.