In CD14.Mn.MHC2hi cluster the up-regulation of the following genes of interest was detected in cancer: SDC2, MS4A4A, MX1, FKBP5, OAS1, CEBPD, FABP5, DAPK1, CD63, IFITM1, VSIG4, and CXCR4 annotated with interferon alpha/gamma, MYC targets, angiogenesis, glycolysis, oxidative phosphorylation, MTORC1 signaling, and HSF1 activation. The gene discussed is HSF1; the disease is cancer.