Injection of the SLC7A11 inhibitor Erastin reduced the expression of SLC7A11 and GPx4, indicating that 14 days of aerobic exercise can activate the Nrf2/SLC7A11/GPx4 pathway, thereby reducing sensitivity to ferroptosis in the ischemia–reperfusion brain model (Liu et al., 2022). Here, GPX4 is linked to ischemia.