The physiological mechanisms by which aerobic exercise prevents and delayed AD occurrence include enhancing mitochondrial function (Bernardo et al., 2016), mitigating cerebral oxidative stress response (Koo and Kang, 2019), reducing abnormal phosphorylation of Tau proteins (Fang et al., 2018), and suppressing neuroinflammatory reactions (Ryan and Kelly, 2016) and so on. Here, MAPT is linked to Alzheimer disease.