Likewise, in both PANC1 and Miapaca‐2 pancreatic cancer cells, USP10 overexpression increased DIRAS2 levels and inactivated pERK1/2 in a dose‐dependent manner (Figure 1C, top left), whereas USP10 knockdown decreased DIRAS2 levels and activated pERK1/2 (Figure 1C, top right). Here, USP10 is linked to familial pancreatic carcinoma.