The authors identified a total of six proteins involved in complement activation [complement C1q subcomponent subunit A (C1QA), complement C5], lipoprotein metabolism [apolipoprotein D (APOD) and C-III (APOCC3)] and platelet activation [platelet glycoprotein Ib alpha chain (GP1BA), platelet basic protein (PPBP)] to be significantly upregulated in serum EV of patients with myocardial infarction compared to patients with stable angina. Here, APOD is linked to myocardial infarction.