Kaplan-Meier curves results showed that the survival rate of ESCC patients in the high HMGB1 group was significantly lower than that in the low HMGB1 group (95%CI=0.120-0.703, P<0.001) (Figure 5A), and the survival rate of ESCC patients in the high IDO group was significantly lower than that in the low IDO group (95%CI=0.109-0.560, P=0.013) (Figure 5B). The gene discussed is IDO1; the disease is esophageal squamous cell carcinoma.