Infection with SARS-CoV-2 is thought to result in dysregulated immune response, myeloid cell infiltrates, activation and recruitment of monocytes, macrophages, and neutrophils, as well as the formation of neutrophil extracellular traps (NETs), complement system hyperactivation, and subsequently massive production of systemic pro-inflammatory factors, such as C-reactive protein (CRP), D-dimer, ferritin, interleukin-1 (IL-1), IL-6, and tumor necrosis factor-α (TNF-α). This evidence concerns the gene TNF and infection.