CD40LG and coccidioidomycosis: To diagnose an early coccidioidal infection, enzyme immunoassays (EIAs) for anticoccidial immunoglobulin M (IgM) and immunoglobulin G (IgG) are commercially available, and they are twice as sensitive as standard immunodiffusion-based tests for traditional tube precipitin (IDTP) or complement-fixing (IDCF) anticoccidial antibodies [11].