Although studies related to the role of the TNIP1 gene in the pathogenesis of AIT are limited, it has been suggested that HT is one of the possible phenotypes of dysfunction in A20 haplogroups and that TNFAIP3 may be one of the genetic susceptibility factors for certain AITD (64, 65). This evidence concerns the gene TNFAIP3 and hematocrit.