IngenuityTM Pathway Analysis (IPA) showed that many of the most significantly overexpressed genes in leiomyoma, such as GRIA2, GRIN2A, DCX, STMN2, NEFH, GPR10, SCG2 and SALL1 are all direct targets of REST-mediated long-term repression (Fig. 1A). The gene discussed is NEFH; the disease is leiomyoma.