Since PRICKLE1 is an important mediator of WNT/PCP signaling and is reported to negatively regulate WNT/ β-catenin through ubiquitination of dissheveled 335, we wanted to investigate if the loss of PRICKLE1 expression is related to the widely reported aberrant activation of WNT/ β-catenin pathway in uterine fibroids. This evidence concerns the gene PRICKLE1 and uterine corpus leiomyoma.