Similar to our transcriptomic scRNA seq dataset, we quantified MCs co-expressing LOC102140229 and CMA1. Consistent with our data, CMA1 and LOC102140229 (the α/β-like tryptase ortholog) expressions were associated with severe disease, being significantly enriched in MCs from the higher-burden 4-week granulomas, (OR = 0.27, p < 1×10−29, and OR = 1.68, p < 1×10−5, respectively). Here, CMA1 is linked to Granuloma.