TIRR amplification is frequently observed in a wide range of cancers 77,109,110, with the highest frequencies found in breast invasive carcinoma (4.06%, cholangiocarcinoma (2.78%) and diffuse large B-cell lymphoma (2.08%), according to cancer genomics data sets from cBioPortal (Supplementary Figure 12d). Here, NUDT16L1 is linked to diffuse large B-cell lymphoma.