CST3 and autosomal dominant polycystic kidney disease: Additionally, a randomized controlled, 3-month pilot trial (KETO-ADPKD) with 66 ADPKD patients comparing periodic water fasting vs. a ketogenic diet vs. no dietary change confirmed safety and feasibility, and found a significant reduction in body fat, and a significant improvement in eGFR (based both on creatinine and cystatin C).24