TGFB1 and Hepatic fibrosis: In contrast, Sja-miR-71a derived from theS. japonicum egg-released EVs was reported to suppress the pathological progression of hepatic fibrosis by inhibiting the TGF-β1/SMAD and IL-13/signal transducer and activator of transcription 6 (STAT6) pathwaysvia directly targeting semaphorin 4D[54].