In lung cancer patients, lncRNA GIAT4RA, lncRNA AATBC, lncRNA Sirt1-AS, and NSE had a higher area under the ROC curve (66.7, 77.3, 82.5, 98.7%, respectively, P = 0.030, <0.001) with sensitivity (60, 70, 90, 98%, respectively) and specificity (80, 80, 75, 100%, respectively). The gene discussed is ENO2; the disease is lung cancer.