AXIN1 and Parkinson disease: Moreover, genetical knockdown of Axin via shRNA lentivirus, a negative regulator of Wnt/β-catenin signaling and a scaffold protein in Dc, improves behavioral functions, protects the nigral DAergic neurons, and promotes mitochondrial biogenesis in substantia nigra pars compacta in 6-OHDA-induced rat models of PD [156].