Correlation analysis (Extended Data Fig. 3g–h) showed that glucagon secretion in T1D mice, unlike what was seen in ND NOD mice, was insensitive to changes in plasma glucose (P = 0.019 vs ND), a defect that was partially rectified by CYN154806 (P = 0.007 vs T1D without CYN154806). This evidence concerns the gene GCG and type 1 diabetes mellitus.