Although we have not found transcriptional up-regulation of PFKFB3 in the “loser” HPAP datasets, we found that APC/Cdh1 E3 ubiquitin ligase that regulates PFKFB3 stability (Tudzarova et al, 2011) was down-regulated in T2DHPAP, in line with PFKFB3 protein up-regulation in diabetes (Wigger et al, 2021). This evidence concerns the gene PFKFB3 and diabetes mellitus.