Interestingly, MAIP1 immunopositivity marked specifically β-cells in DS+vehicle and human T2D donors and its sharp reduction below 1% upon PFKFB3 inhibition in h-βTG mice indicated a potential elimination of MAIP1-positive β-cells connected to the treatment (Huang et al, 2010). This evidence concerns the gene MAIP1 and type 2 diabetes mellitus.