PFKFB3 and type 2 diabetes mellitus: From the available T1D and T2D single nucleotide polymorphism (SNP) pool of the HPAP database of Genotypes and Phenotypes (dbGAP), PFKFB3 polymorphism rs1983890 interacted specifically with collective SNPs of ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 (AGAP1), and the anti-apoptotic gene, the matrix AAA peptidase interacting protein 1 (MAIP1) (Opalinska & Janska, 2018).