As these cell-lines are unusual amongst neuroblastoma lines in having MYC (c-MYC) amplification [35], and c-MYC-mediated global transcription is altered by glutamine deprivation [36], we posited that the relative sensitivity of CHLA-15/20 to GSK3203591 may be related to enhanced glutamine pathway dependence. The gene discussed is MYC; the disease is neuroblastoma.