In fact, impairments in both catecholamines in the PFC have been closely linked to cognitive deficits.(Nelson et al., 2011) It should be noted that dopamine clearance in the PFC is mediated by promiscuous uptake through either the dopamine transporter or the NE transporter.(Carboni et al., 1990) Moreover, dopamine has a higher affinity for the NE transporter than NE itself.(Raiteri et al., 1977) Since the number of NE transporters in the PFC of old mice was significantly decreased, cortical dopamine transmission may be compromised due to an insufficient reuptake rate. This evidence concerns the gene SLC6A3 and Cognitive impairment.