H. pylori-positive infection with G-allele PNPLA3 was significantly associated with higher proportion of patient with MASH (84%), versus H. pylori-negative status with G-allele PNPLA3 (47%), H. pylori-positive infection without G-allele PNPLA3 (17%), and H. pylori-negative status without G-allele PNPLA3 (6%) (p<0.001) (Fig 6A). This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.