Previous reports have shown that abnormal staining of the nuclear structural protein Lamin B1 was observed in cells derived from TDP-43 mutant patients.49 However, this abnormal staining was not observed in the induced neurons derived from C9orf72 mutation carriers50 or in post-mortem samples of the motor cortex from C9orf72 patients.51 Consequently, the morphology of the nuclear lamina in ALS remains a subject of controversy. Here, TARDBP is linked to amyotrophic lateral sclerosis.