Earlier studies on the nuclear pore complex (NPC) have revealed disrupted nucleoporins in SOD1-G93A transgenic mice52 and in post-mortem spinal cord samples from patients with sporadic ALS53,54 and FUS-ALS.55 Here, we evaluated the morphology of the nuclear lamina and nucleoporins of LMNs of FusWT/H509D mice. The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.