Narrowing down from the antigen‐specific synaptic contacts described in a previous study, we indicated that the MIF‐CD74 ligand–receptor pair is the key player in the C1QC+ TAMs – CD8+CXCL13+ Tex cell axis.[9] We showed that C1QC+ TAMs predict a poor prognosis in ESCC patients and show high enrichment with CD8+CXCL13+ Tex cells in LN and tumor samples after chemotherapy. This evidence concerns the gene CD8A and neoplasm.