PPP1R15A and heart failure: These data show that the BM genotype had no impact on the susceptibility of Ppp1r15aΔC/ΔC or the resistance of WT littermates to irradiation-induced heart failure, changes in heart geometry and cachexia (Figure 1E and F and see Supplementary material online, Figure S1E and F), suggesting that loss of PPP1R15A activity in immune cells did not contribute to cardiac cachexia.