PPP1R15A and pulmonary fibrosis: A previous study examining wound healing, showed that mice lacking PPP1R15A exhibited accelerated wound closure, increased number of myofibroblasts, and elevated collagen production.43 A recent report has also shown that mice lacking Ppp1r15a show increased pulmonary fibrosis in response to the DNA damage-inducing chemical bleomycin.44 Taken together, these data suggest that the PPP1R15A may play an important role in the negative regulation of fibrosis pathways.