This monoclonal antibody has been validated to block the functional activity of GDF15, whereby mAB2 rapidly reversed the weight loss induced by recombinant GDF15 as opposed to mice receiving an isotype control.30 To investigate whether GDF15 was driving cachexia we analysed whether mAB2 could inhibit loss of body weight in irradiated Ppp1r15aΔC/ΔC male and female mice. The gene discussed is GDF15; the disease is Cachexia.