Weight loss is strongly associated with adverse outcomes in patients with chronic heart failure.33 In addition, GDF15 has been identified as an important predictor of mortality in patients with heart failure.9 To investigate the association between GDF15 and cardiac cachexia we analysed the BIOSTAT-CHF cohort, which included 2516 patients with worsening signs and/or symptoms of heart failure.17 Protein intake in 24-h urine was calculated by the Maroni formula. Here, GDF15 is linked to congestive heart failure.