IFNA1 and infection: In conclusion, despite the robust viremia, strong immune responses, severe dengue symptoms, and even lethal infections observed in these immunocompromised mice, these models have several limitations: (a) highly reliant on adapted strains; (b) mice perish from central nervous system infection; (c) absence of natural immune responses thereby impacting its suitability for vaccine research; (d) cytokine storms under IFN signalling suppression.