In AG129 mice, infection with DENV-1 leads to increased IL-1α/6/10/12 (p40)/12 (p70), IFN-γ, and G-CSF [59]; DENV-2 infection results in elevated IFN-γ, IL-6, and TNF-α [55]; DENV-3 infection induces upregulation of TNF-a, IFN-γ, IL-3/4/6/10/12p40/12p70, CCL2/3/4/5 and G-CSF [58,59]; while DENV-4 infection causes an increase in TNF-α, IFN – γ, IL – 1 α/6/10/12(p40), CXCL1, CCL2/3//4//5 and G-CSF [97]. This evidence concerns the gene TNF and infection.